VUOS multi-purpose pilot plant is well-equipped with a range of glass-lined, stainless steel and rubber-lined reactors for flexible batch-wise production. They are grouped into production trains for a wide range of chemical and physical processes. Sufficient support by rectification units and auxiliary operations (e.g. for isolation of products) makes VUOS a good partner for you.
We are able to develop processes based on our own know-how, or to scale-up and/or optimise existing processes for full commercial production. We co-operate with interesting outsourcing partners on new important pharma-projects.
Pilot plant production is mostly orientated towards VUOS custom syntheses activities [usually under secrecy agreement] ranging in volume from ten kilos to ten tons.
Production is mainly directed into the field of pharmaceutical intermediates ["starting materials"].
The manufacturing service is supported by a highly experienced team of chemists and chemical engineers, with a special expertise in adapting processes and plant layout to manufacture a wide range of speciality/fine chemicals (see our Product List).
We are able to handle some obnoxious/hazardous chemicals, e.g.
Production unit equipment
Reactors
|
Material |
Total volume [l] |
Size |
Number |
|
|---|---|---|---|---|
|
From [l] |
To [l] |
|||
|
Glass Lined |
99 300 |
250 |
6 000 |
63 |
|
Stainless Steel |
28 000 |
400 |
6 000 |
28 |
Distillation Equipment
|
Unit |
Material |
Boiler [l] |
Theoretical Plates |
Pressure [mbar] vaccum |
Temperature [oC] |
Using |
|---|---|---|---|---|---|---|
|
4x |
SS |
500-3500 |
20-96 |
4 -100 |
up to 200 |
distillation, rectification |
|
11x |
Glass lined |
400-6300 |
5-60 |
5-100 |
up to 200 |
azeotropic rectification |
Autoclaves for hydrogenation and pressure reaction
|
Volume [l] |
Material of construction |
Max. operating pressure [MPa] |
Max. operating temperature [°C] |
|---|---|---|---|
|
0.5 - 1000 |
SS |
60 |
250 |
|
0.25 - 3 |
Glass |
1.2 |
200 |
|
100 - 300 |
CS, Hastelloy C4 |
12 |
140 |
|
100 |
Ceramic |
40 |
200 |
Low temperature equipment
|
Volume |
Material of construction |
Min. operating temperature [°C] |
|---|---|---|
|
5 - 100 |
Glass |
-40 |
|
63 - 600 |
Glass Lined |
-80 |
Phosgenation unit equipment
|
Volume |
Material of construction |
Max. operating temperature [°C] |
|---|---|---|
|
250 - 1600 |
Glass Lined |
150 |
+ drying, rectification, distillation and filtration capacity
Kilolab and Semi-pilot equipment
|
Material |
Total volume [l] |
Size |
Number |
|
|---|---|---|---|---|
|
From [l] |
To [l] |
|||
|
Glass Lined |
6 000 |
200 |
1 500 |
6 |
|
Stainless Steel |
4 000 |
200 |
1 500 |
4 |
|
Glass |
2 000 |
50 |
100 |
25 |
|
Glass Evoporators |
200 |
50 |
100 |
2 |
+ drying, distillation and filtration capacity
Clean Room class D
|
Material |
Total volume [l] |
Size |
Number |
|
|---|---|---|---|---|
|
From [l] |
To [l] |
|||
|
Glass Lined |
1 000 |
400 |
600 |
2 |
|
Stainless Steel |
1 000 |
400 |
600 |
2 |
+ drying, distillation and filtration capacity
Laboratory Equipment
Rectification Distillation
Rectification stills equipped with high performance packing (SS, Sulzer type), ranging in performance up to 60 theoretical plates.
Rectification still with conventional packing, separation performance 100 theoretical plates. Atmospheric / vacuum operation, fully automatic control system.
Distillation
Short-path evaporator - glass/stainless steel, operating temperature up to 250 deg C, vacuum down to 0.5 torr, 0.03m2 and 0,1m2
Hydrogenation
Experience collected mainly in areas of catalytic hydrogenation of nitro-groups (to resp. amines), carbonyl-groups (to alcohols), oximes (to amino-groups) and reductive cyclisation.
Operating conditions: pressure up to 20 bar, batch volume up to 8 l, temperature up to 150 deg C. Automatic control & monitoring, possibility to be run in a semi-continuous regime (reactants feeding during reaction by metering pumps).
Pressure operation
Typical operations include alkylations, aminations, oxidations, pressure re-crystallisation.
Operating conditions: pressure up to 50 bar, heating up to 250°C (automatical control), possibility to be run in a semi-continuous way (see above).
Lower-temperature syntheses
Used mainly for special chlorinations (using PCl5) and nitrations in jacketed glass equipment. Operating conditions: temperature typically at - 25°C, batch volume up to 20 l, semi-continuous regime possible, inert gas blanketing as a standard.
Auxiliary equipment
In addition, the reactors are equipped with various accessories for distilling, azeotropic distillation, reflux, and computer control system of operating conditions. The apparatuses are connected with absorption and adsorption units. Numerous tanks, pumps, piping [stainless, glass, plastic] and hose connection sections [PTFE], mixers, dryers and heat transfer systems [steam, brine and hot oil] are available.
